We argue that in implanted neurotechnology research, participants and researchers experience what Henry Richardson has called “moral entanglement.” Participants partially entrust researchers with access to their brains and thus to information that would otherwise be private, leading to created intimacies and special obligations of beneficence for researchers and research funding agencies. One of these obligations, we argue, is about continued access to beneficial technology once a trial ends. We make the case for moral entanglement in this context through exploration of (...) participants’ vulnerability, uncompensated risks and burdens, depth of relationship with the research team, and dependence on researchers in implanted neurotechnology trials. (shrink)

1 Evidence-based policy requires researchers to provide the answers to ecological questions that are of interest to policy makers. To find out what those questions are in the UK, representatives from 28 organizations involved in policy, together with scientists from 10 academic institutions, were asked to generate a list of questions from their organizations. 2 During a 2-day workshop the initial list of 1003 questions generated from consulting at least 654 policy makers and academics was used as a basis for (...) generating a short list of 100 questions of significant policy relevance. Short-listing was decided on the basis of the preferences of the representatives from the policy-led organizations. 3 The areas covered included most major issues of environmental concern in the UK, including agriculture, marine fisheries, climate change, ecosystem function and land management. 4 The most striking outcome was the preference for general questions rather than narrow ones. The reason is that policy is driven by broad issues rather than specific ones. In contrast, scientists are frequently best equipped to answer specific questions. This means that it may be necessary to extract the underpinning specific question before researchers can proceed. 5 Synthesis and applications. Greater communication between policy makers and scientists is required in order to ensure that applied ecologists are dealing with issues in a way that can feed into policy. It is particularly important that applied ecologists emphasize the generic value of their work wherever possible. (shrink)

My recent edition of Antigone was not intended primarily as a contribution to textual criticism. I did no work on the manuscripts, and little work on tracing the sources of old conjectures. Nevertheless, some of my thoughts on the text may merit fuller discussion than I was able to give them in a beginners' edition. And there have been more recent developments: in particular we now have a new Oxford Text of Sophocles with a companion volume of Sophoclea, and I (...) have benefited from stimulating discussion with Dr David Kovacs, who has kindly allowed me to see a draft of some forthcoming notes of his own. (shrink)

Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) (...) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. (shrink)

The goal of this paper is to sketch an account of Kant’s signature metaphysical doctrine (transcendental idealism) that (a) has no supporters – as far as I am aware – in the contemporary literature, and (b) draws its primary motivation (as interpretation) from considerations regarding our practical situation and needs as agents. -/- The consideration I focus on here is that people not only have mental and moral features, but they also appear to us – in our daily experience – (...) to have such features: “[w]e can perceive virtue in our experience (Wir können in der Erfahrung wohl Tugend wahrnehmen)” (24: 906). The same presumably goes for vice: When I see you casually torturing a cat, you appear to me to be brown-haired, wearing jeans, moving your arms, laughing, and so on, but you also appear to me to be vicious and cruel. Your character shines through in your actions. I can then make a defeasible inference from those appearances to the moral reality. -/- Such appearances and inferences play a central role in our practices of praise, blame, forgiveness, and punishment. An interpretation of transcendental idealism that gives primacy to the practical will thus seek to analyze the concepts of experience, acquaintance, and appearance/phenomenon in a capacious-enough way that they can apply to mental and moral features too. If successful, such an interpretation would have a clear practical advantage over those that leave us merely conjecturing from experiences of bodies, gestures, and secondary qualities to moral features that do not appear, or even to the non-appearing features of a distinct set of things. (shrink)

First of all, I just want to say that in my opinion this is an interesting and thought-provoking book, and a badly needed corrective to certain mistaken assumptions about James. I find myself very much in sympathy with many of its main points. Some of the things I have to say in the following may— or perhaps may not—be thought to disagree with some of what Professor Brown has argued in his book. If that is so, it should be (...) taken only as an indication of the degree to which William James on Radical Empiricism and Religion stimulates philosophical thought. Similarly, the essay I found myself preparing for this occasion seems in the end to have a lot more to do with what I think about James than, on the surface, it does with Professor Brown’s book: again, I would wish this to be seen as a compliment to the high quality of his work (which is certainly the way I see it), since everything I might have come up with here is in response to my reading of his book. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 39.3 (2001) 442-443 [Access article in PDF] Steven Nadler, editor. The Cambridge Companion to Malebranche. Cambridge Companions. New York: Cambridge University Press, 2000. Pp. xi + 319. Cloth, $54.95. With his own Cambridge Companion, the seventeenth-century French philosopher Nicolas Malebranche has at last arrived in the English speaking world. As editor Nadler puts it, "Malebranche was widely recognized by his philosophical and theological (...) contemporaries... as an intellectual force to be reckoned with, a bold... synthesizer of... St. Augustine and Descartes and a systematic thinker of the first rank" (1). Yet until the relatively recent arrival of books or translations by scholars such as Nadler, McCracken, Jolley, Schmaltz, and Riley, Malebranche has largely been treated by Anglo-American scholars as merely the solitary proponent of the allegedly rather silly doctrine of occasionalism. The tide is now turning, and we may expect that over the next few years Malebranche's wide-ranging sophistication and significance will be more widely appreciated. Invaluable to that end will be Nadler's volume, which is of great interest both to those new to Malebranche and to seasoned scholars, for it presents accessible yet thorough introductions to Malebranche's many interesting doctrines—concerning self-knowledge, vision in God, continuous creation, occasionalism, theodicy, grace, freedom, morality, etc.—as well as raises important questions for future research. All of the essays Nadler has assembled are by well-known scholars, and all are worthwhile.The first point to make is that occasionalism—the view that God is the only true cause, and that finite substances lack all true causal power—was neither silly, nor was Malebranche its only proponent. As Nadler's own essay makes clear, the doctrine (or variations thereof) has roots in medieval philosophy as well as in Descartes, and was favored by other Cartesians preceding Malebranche, such as Cordemoy, la Forge, Geulincx, and Clauberg; further, Malebranche offered numerous distinct arguments for it, and, as evidenced in essays by Schmaltz, Rutherford, Kremer, and Riley, intended it to fit with his other metaphysical views in a complete and coherent system. Even if, as some of these same authors suggest, Malebranche failed to get everything to fit quite right, it's at least clear that the oft-raised charge that occasionalism was merely an ad hoc solution to the Cartesian mind-body problem is unjustified. There is of course room to disagree with certain details here: I've argued elsewhere, for example against Nadler, that despite evidence to the contrary Malebranche does not invoke continuous creation as an argument for occasionalism, and, in effect, against Kremer, that Malebranche can succeed in reconciling occasionalism and his conception of free will. But then the fact that scholars can disagree on points such as these is precisely evidence that Malebranche is a rich subject of study.Different essays have different virtues. Some are especially strong in philosophical analysis. Schmaltz provides penetrating analyses of Malebranche's doctrine that we see [End Page 442] all things "in God" as well as of related issues (such as the distinction between the intellectual and the sensible), and also traces their roots in or ramifications for thinkers such as Augustine, Descartes, Arnauld, and Regis; Kremer, too, does an impressive job disentangling the many discrete threads in Malebranche's theory of free will. Essays by Moreau and Riley are particularly useful for their overview or synthetic nature: Moreau presents the many points of contention in the decades-long dispute between Malebranche and Arnauld, while Riley makes explicit the implications that many of the doctrines discussed by other contributors have for Malebranche's moral theory (in the process perhaps implicitly supporting the claim that Malebranche's moral theory may be essential for understanding his metaphysics). Brown's and Robinet's contributions, the former detailing Malebranche's positive influence on or critical reception by figures such as Locke, Leibniz, Berkeley, Hume, and Reid, the latter focusing on disputes between Malebranche, Arnauld, and Leibniz, are essential for those interested (as all should be) in working Malebranche into standard undergraduate courses on modern philosophy, and will also be... (shrink)

Ubiquitous healthcare is an emerging area of technology that uses a large number of environmental and patient sensors and actuators to monitor and improve patients' physical and mental condition. Tiny sensors gather data on almost any physiological characteristic that can be used to diagnose health problems. This technology faces some challenging ethical questions, ranging from the small-scale individual issues of trust and efficacy to the societal issues of health and longevity gaps related to economic status. It presents particular problems in (...) combining developing computer/information/media ethics with established medical ethics. This article describes a practice-based ethics approach, considering in particular the areas of privacy, agency, equity and liability. It raises questions that ubiquitous healthcare will force practitioners to face as they develop ubiquitous healthcare systems. Medicine is a controlled profession whose practise is commonly restricted by government-appointed authorities, whereas computer software and hardware development is notoriously lacking in such regimes. (shrink)

In this article I propose the concept of ‘non-cinema’. The term points to that which is excluded from cinema, and accordingly I seek to explore the various reasons for these exclusions, in particular the political/ideological ones, together with how these exclusions are manifested on an aesthetic level. Instead of André Bazin's founding question regarding what is cinema, therefore, this essay asks what cinema is not – and why. This question is of redoubled importance in an age of technological change: not (...) only are nearly all films now not made using the traditional equipment of filmmaking (analogue cameras, linear editing systems, polyester film stock), but nor do they get exhibited in traditional theatrical venues (instead circulating on DVD and related formats, and online). On a related note, increasing numbers of filmmakers actively are moving away from feature filmmaking, e.g. into television. The essay focuses in particular on ‘non-cinematic’ works by Philippine director Khavn de la Cruz and American director Giuseppe Andrews. Formally, I argue that their films deliberately embrace that which is perceived as non-cinematic in order to put forward what Argentine philosopher Enrique Dussel might define as a ‘barbarian’ film-philosophical vision of the world, which is reminiscent of Antonio Negri's concept of multitude, and which also has an ethical dimension in that it proposes the inclusion of the overlooked and the dispossessed, and of the darkness that necessarily accompanies the light. (shrink)

This book argues that justice often governs apologies. Drawing on examples from literature, politics, and current events, Cohen presents a theory of apology as corrective offers. Many leading accounts of apology say much about what apologies do and why they are important. They stop short of exploring whether and how justice governs apologies. Cohen argues that corrective justice may require apologies as offers of reparation. Individuals, corporations, and states may then have rights or duties regarding apology. Exercising rights to apology (...) or fulfilling duties to provide them are ways of holding one another mutually accountable. By casting rights and duties of apology as justifiable to free and equal persons, the book advances conversations about how liberalism may respond to historic injustice. Apologies and Moral Repair will be of interest to scholars and advanced students in ethics, political philosophy, and social philosophy. (shrink)

Multinational corporations face a litany of challenges regarding ethical decision-making as they traverse new variables in each country they operate in. Presented here is a new approach to ethical decision-making research for multinational corporations with the inclusion of moral virtues, national culture, and a feedback mechanism. The new proposed model builds off of the existing work by Trevino’s Person-Situated Interactionist Model. Hofstede’s work on individual national culture characteristics is used to move the conversation forward by explaining the relationships between individual (...) moderators in Trevino’s model and the effect of national culture on them. The new proposed model recommends the inclusion of moral virtues, with honesty and integrity as examples, as individual moderators in the decision-making process based on previous work. It contributes to the literature by introducing moral virtues into traditional ethical decision-making process models and introduces a new variable with a feedback mechanism for future learning. The paper concludes with recommendations for the future direction of research for ethical decision-making models for multinational organizations. (shrink)

This paper considers the relation of corrective to distributive justice. I discuss the shortfalls of one sort of account that holds these are independent domains of justice. To support a more modest claim that these are sometimes independent domains of justice, I focus instead on the case of apologies. Apologies are sometimes among the measures specified by corrective justice. I argue that the sorts of injustices that apologies can help to correct need not always be departures from ideals specified by (...) distributive justice. Apologies and the moral relations they engage might thus be parts of a domain of justice that is neither distributive nor dependent on distributive justice. (shrink)

abstract Contractarianism roots moral standing in an agreement among rational agents in the circumstances of justice. Critics have argued that the theory must exclude nonhuman animals from the protection of justice. I argue that contractarianism can consistently accommodate the notion that nonhuman animals are owed direct moral consideration. They can acquire their moral status indirectly, but their claims to justice can be as stringent as those among able‐bodied rational adult humans. Any remaining criticisms of contractarianism likely rest on a disputable (...) moral realism; contractarianism can underwrite the direct moral considerability of nonhuman animals by appealing to a projectivist quasi‐realism. (shrink)

In this essay I describe how contractarianism might approach interspecies welfare conflicts. I start by discussing a contractarian account of the moral status of nonhuman animals. I argue that contractors can agree to norms that would acknowledge the “moral standing” of some animals. I then discuss how the norms emerging from contractarian agreement might constrain any comparison of welfare between humans and animals. Contractarian agreement is likely to express some partiality to humans in a way that discounts the welfare of (...) some or all animals. While the norms emerging from the contract might be silent or inconsistent in some tragic or catastrophic cases, in most ordinary conflicts of welfare, contractors will agree to norms that produce some determinate resolution. What the agreement says can evolve depending upon how the contractors or the circumstances change. I close with some remarks on contractarian indeterminacy. (shrink)

Contemporary Debates in Applied Ethics features pairs of newly commissioned essays by some of the leading theorists working in the field today. Brings together fresh debates on eleven of the most controversial issues in applied ethics Topics addressed include abortion, affirmative action, animals, capital punishment, cloning, euthanasia, immigration, pornography, privacy in civil society, values in nature, and world hunger. Lively debate format sharply defines the issues, and paves the way for further discussion. Will serve as an accessible introduction to the (...) major topics in applied ethics, whilst also capturing the imagination of professional philosophers. (shrink)

What makes a policy work? What should policies attempt to do, and what ought they not do? These questions are at the heart of both policy-making and ethics. Philosophy, Ethics and Public Policy: An Introduction examines these questions and more. Andrew I. Cohen uses contemporary examples and controversies, mainly drawn from policy in a North American context, to illustrate important flashpoints in ethics and public policy, such as: public policy and globalization: sweatshops; medicine and the developing world; immigration marriage, (...) family and education: same-sex marriage; women and the family; education and Intelligent Design justifying and responding to state coercion: torture; reparations and restorative justice the ethics of the body and commodification: the human organ trade, and factory farming of animals. Each chapter illustrates how ethics offers ways of prioritizing some policy alternatives and imagining new ones. Reflecting on various themes in globalization, markets, and privacy, the chapters are windows to enduring significant debates about what states may do to shape our behavior. Overall, the book will help readers understand how ethics can frame policymaking, while also suggesting that sometimes the best policy is no policy. Including annotated further reading, this is an excellent introduction to a fast-growing subject for students in Philosophy, Public Policy, and related disciplines. (shrink)

This paper argues against an individualist challenge to the possibility of corporate apologies. According to this challenge, corporations always and only act through their members; thus they are not the sorts of entities that can apologize. Consequently there can be no corporate apologies. Against this challenge, this paper argues that even if corporate acts can be analyzed as acts by individuals within certain relationships, there can still be corporate apologies. This paper offers a noneliminative individualist account of such apologies. The (...) paper also responds to various substantive objections to the possibility of such apologies. (shrink)

The article criticizes arguments by Henry Shue, Cass Sunstein, and Stephen Holmes that rights entail enforceable positive duties.

This book provides rigorous but accessible scholarship, ideal for students in philosophy and public policy. It includes twelve original essays by world-renowned scholars, each examining a key topic in philosophy and public policy and demonstrating how policy debates can be advanced by employing the tools and concepts of philosophy.

This essay explores whether dependent relationships might justify extending direct moral consideration to nonhuman animals. After setting out a formal conception of moral standing as relational, scalar, and unilateral, I consider whether and how an appeal to dependencies might be the basis for an animal’s moral standing. If dependencies generate reasons for extending direct moral consideration, such reasons will admit of significant variations in scope and stringency.

I focus particularly on the case of the glory seekers. Driven by a foolhardy overestimation of their worth, seekers of glory do not value peace as others do. They may not even value peace at all. Their quest for glory then often obstructs peace, which is perhaps why Hobbes condemns vainglory as irrational. But once we clarify what it is that glory seekers seek, it becomes uncertain that gratifying appetites for glory is necessarily against right reason. If Hobbes is then (...) to say that the laws of nature are the dictates of right reason, he must either show that glory seeking is against right reason, or he must explain why the right reason of glory seekers, which argues against the laws of nature, does not count against the normative force of such laws. (shrink)

In Who’s Afraid of the Unmoved Mover? Postmodernism and Natural Theology, I defend natural theology against its postmodern evangelical detractors, including Myron Bradley Penner. Penner rejects natural theology because it attempts to ground knowledge of God in human reason, and he claims that my treatment of Acts 17:16–34 is fatal to my argument. However, Penner does not engage my explication of the doctrine of general revelation. The catastrophic effects that Penner perceives turn out to be only against a straw man (...) of the version of natural theology that I defend. (shrink)

Hobbes claims that the sovereign's absolute authority is consistent with the subjects' retaining liberties to resist certain commands. In this essay, I explore what it means for subject to authorize a sovereign with a right to command. I show how retained rights are compatible with sovereignty. Though any given subject does not authorize the sovereign to do anything, I argue that the sovereign power is absolute. The sovereign has the most power anyone could command.

Are postmodern philosophy and Christian theology compatible? A surprising number of Christian philosophers and theologians think so. However, these same thinkers argue that postmodern insights entail the rejection of natural theology, the ability to discover knowledge about the existence and nature of God in the natural world. Postmodernism, they claim, shows that appealing to nature to demonstrate or infer the existence of God is foolish because these appeals rely on modernity’s outmoded grounds for knowledge. Moreover, natural theology and apologetics are (...) often hindrances to authentic Christian faith. Notions like objectivity and rationality are forms of idolatry from which Christians should repent. This book carefully examines the nature of truth, rationality, general revelation, and evangelism to show that the postmodern objections fail and that Christians ought to lovingly and faithfully use natural theology and apologetics to defend and commend the Christian faith to a world in need of the knowledge of God. (shrink)

Apologies are key components of moral repair. They can identify a wrong, express regret, and accept culpability for some transgression. Apologies can vindicate a victim's value as someone who was due different treatment. This paper explores whether acts with vicarious elements may serve as apologies. I offer a functionalist account of apologies: acts are apologies not so much by having correct ingredients but by serving certain apologetic functions. Those functions can be realized in multiple ways. Whether the offenders are individuals (...) or collectives, they can sometimes fulfill such functions through third party agents. Having vicarious elements does not necessarily undermine the reparative reasons offenders hope to provide. (shrink)

Introduction to the symposium on the 25th anniversary of the publication of Rawls's Political Liberalism, including overviews of the contributions to the special issue.

The dynamic qualities of friendship sometimes require friends to assess their relationship in light of reasons of reciprocity or moral considerations. Friends sustain their relationship partly by assessing the terms of reciprocity. Sometimes friends must also consider how moral reasons bear on their friendship; friends need to resolve occasional clashes between the demands of friendship and rival moral considerations, and friends must sometimes serve as a moral stewards for each other. I discuss how friends may monitor their relationship without undermining (...) the trust and mutual regard appropriate to friends. (shrink)

Higher education provides crucial public and private goods. Especially in the United States, however, higher education reflects and sometimes compounds enduring inequities and inefficiencies. Higher education, critics argue, inefficiently provides a credential that is often crucial for career advancement but whose value is mainly to signal skills one already had. This paper explores the moral significance of an oversupply of higher education, especially for persons disadvantaged because of uncorrected historic injustice. I review the moral costs of credentials inflation. Focusing on (...) those who already have independent claims to reparation for historic injustice, I set out whether and how some such persons might have additional claims to repair for the increased credential demands for work. I close by considering what sorts of repair corrective justice might prescribe. (shrink)

Besides commanding coercive power, a political authority is supposed to offer directives which ought to exclude private judgment. Any defense of inalienable rights or limited rights of resistance suggests some legitimate residual private judgment. Such retained rights threaten to undermine the binding force of authoritative directives. ;The case of Hobbesian sovereignty typifies this problem. Hobbes claims agents must establish permanent and absolute political authorities, and they can do so only by completely submitting themselves to a sovereign power whose public will (...) stand for their own. Hobbesian political obligation consists in being bound not to act on one's own judgment, but even Hobbes allows for limited rights of resistance. ;Building on the work of Joseph Raz, I show how political authority binds our conduct by providing special reasons not to act on our private judgment. I explain how there can be scope and jurisdictional limitations on political authority, indeed, Hobbesian political authority. Any given subject might not completely authorize political power, but such power can still be absolute. Since private judgment endures in a civil society, subjects are in some position to evaluate the legitimacy of authoritative directives. To the extent authority binds and neither merely advises nor merely coerces, subjects must have reasons why they should not act on their private judgments. (shrink)

Critics often note that our choices may support wrongdoing such as by fostering climate change, perpetuating oppression in the developing world, or benefiting from the avoidable suffering of nonhuman animals. It is unclear what sort of reasons these remote consequences present, especially in conditions of uncertainty. Ethicists commonly warn that ignorance does not necessarily exculpate or release from compensatory burdens for wrongdoing. Moreover at least sometimes, the demandingness of justice might not cancel or defeat the reasons it provides. Sorting out (...) how to forbear or repair injustice (and even how to begin to do these) may be daunting. After discussing how ignorance of moral or empirical considerations bears on blame or praise, I explore whether and how performing or being disposed to provide moral repair might address the demands of justice in light of uncertain remote causes and consequences. I reject the claim that morally conscientious persons must always seek to prevent injustice. (shrink)

Contractarianism is more inclusive than critics (and, indeed, Gauthier) sometimes suggest. Contractarianism can justify equal moral standing for human persons (in some respects) and provide sufficient moral standing for many nonhuman animals to require what we commonly call decent treatment. Moreover, contractarianism may allow that some entities have more moral standing than others do. This does not necessarily license the oppression that liberal egalitarians rightly fear. Instead, it shows that contractarianism may support a nuanced account of moral status.

Friendships are voluntary relationships founded and sustained on reciprocated good will and mutual caring. Individuals in end friendships exhibit a mutual regard that is characteristic of those dispositions by which they spontaneously treat one another as ends. But even the closest of friends face challenges that can pit reasons of reciprocity or considerations of morality against friendship. My focus here is to examine how friends may assess their relationships in light of such challenges. This inquiry may then illuminate how the (...) demands of friendship generate reasons. (shrink)

RésuméLes propriétés dynamiques de l'amitié requièrent parfois que les amis réévaluent leur relation à la lumière de raisons de réciprocité ou de considérations morales. Les amis maintiennent leur relation en partie en évaluant leurs rapports de réciprocité. Ils doivent aussi considérer parfois l'impact de raisons morales sur leur amidé; il leur faut résoudre d'occasionnelles tensions entre les exigences de l'amitié et certaines considérations rivales d'ordre moral, et ils doivent agir parfois comme surveillants l'un pour l'autre dans l'ordre moral. Je discute (...) ici la façon dont les amis peuvent gérer leur relation sans compromettre la confiance et le respect mutuels qui sont appropriés entre amis. (shrink)

This book brings together leading interdisciplinary scholars to broaden and deepen the conversation about moral injury. In original essays, the contributors present new research to show how the humanities are crucial for understanding the expressions, meaning, and significance of moral injury. Moral injury is the disorientation we suffer when we are complicit in some moral transgression. Most existing work addresses moral injury from a clinical or neuroscientific perspective. The essays in this volume show how the humanities are crucial for understanding (...) the meaning and significance of moral injury, as well as suggesting how to grapple with its lived challenges. The chapters address the conceptual, sociological, historical, and ritualistic dimensions of moral injury across three thematic sections. Section 1 explores how tools of the humanities provide new lenses for understanding conceptual and genealogical themes about moral injury. Section 2 highlights the experiences of moral injury in combat soldiers, law enforcement, and noncombatants such as photojournalists. These chapters examine the power and limits to theorizing moral phenomena by appeals to lived experience. Section 3 considers how humanistic inquiry illuminates important dimensions of the aftermath of moral injury beyond the scope of clinical research. These chapters consider how ritual, relationship repair, and atonement might shape the ways people navigate moral injury and consider how such responses shape our understandings of what we owe to one another. Moral Injury and the Humanities: Interdisciplinary Perspectives is an essential resource for researchers and advanced students in philosophy, religious studies, literature, journalism, and the arts who are interested in moral injury. (shrink)

To decode the function and molecular recognition of several recently discovered cytosine derivatives in the human genome – 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine – a detailed understanding of their effects on the structural, chemical, and biophysical properties of DNA is essential. Here, we review recent literature in this area, with particular emphasis on features that have been proposed to enable the specific recognition of modified cytosine bases by DNA-binding proteins. These include electronic factors, modulation of base-pair stability, flexibility, and radical changes (...) in duplex conformation. We explore these proposals and assess whether or not they are supported by current biophysical data. This analysis is focused primarily on the properties of epigenetically modified DNA itself, which provides a basis for discussion of the mechanisms of recognition by different proteins. 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine have recently been discovered in mammalian DNA and appear to have essential regulatory roles. Here, we summarize recent investigations into their effects on the structural, chemical, and biophysical properties of DNA, an understanding of which is essential to decoding their behavior in the genome. (shrink)

This chapter contains sections titled: Why Do We Date? A Brief History of Dating Calculated Relationship Initiation and Maintenance All “Perfect” Dating Relationships Stumble, but Not in the Same Way Dating as a Particular Genre of Friendship Against Unconditional Love Conclusion.

Graphical AbstractWhereas clathrin-mediated endocytosis (CME) exists in all eukaryotic cells, we first detect classical dynamin in Ichthyosporid, a single-cell, metazoan precursor. Based on a key functional residue in its pleckstrin homology domain, we speculate that the evolution of metazoan dynamin coincided with the specialized need for regulated CME during neurotransmission.

New York: Cambridge University Press, 2009. Pp. 436. $90.00 (cloth).